References:
Aleccia, J. (2023, April 28). How do Ozempic, Wegovy and Mounjaro work? What to know about drugs promising weight loss. ABC7 Eyewitness News. https://abc7.com/weight-loss-drugs-ozempic-what-is-mounjaro-wegovy/13192740/
Cedó L, Santos D, Roglans N, Julve J, Pallarès V, Rivas-Urbina A, Llorente-Cortes V, Laguna JC, Blanco-Vaca F, Escolà-Gil JC (2017). "Human hepatic lipase overexpression in mice induces hepatic steatosis and obesity through promoting hepatic lipogenesis and white adipose tissue lipolysis and fatty acid uptake". Doi: 10.1371/journal.pone.0189834
http://music.arts.uci.edu/dobrian/CD.music.lang.htm
Karim, I. (2016). BioGeometry Signatures: Harmonizing the Body’s Subtle Energy Exchange with the Environment. CreateSpace Independent Publishing Platform.
James, J. (1995). The Music of the Spheres: Music, Science, and the Natural Order of the Universe. Copernicus.
Wheeler, M. (2004, March). Signal Discovery? A Los Angeles scientist says living cells may make distinct sounds, which might someday help doctors “hear” diseases. Smithsonian Magazine. http://www.smithsonianmag.com/science-nature/signal-discovery-104663195/
http://www.sciencegymnasium.com/2013/07/scientist-prove-dna-can-be-reprogrammed.html#more
The Music of the Spheres: Music, Science, and the Natural Order of the Universe Paperback – April 24, 1995
For centuries, scientists and philosophers believed that the universe was a stately, ordered mechanism, both mathematical and musical. The perceived distances between objects in the sky mirrored (and were mirrored by) the spaces between notes forming chords and scales. The smooth operation of the cosmos created a divine harmony that composers sought to capture and express. Jamie James allows readers to see how this scientific philosophy emerged, how it was shattered by changing views of the universe and the rise of Romanticism, and to what extent it survives today - if at all. From Pythagoras to Newton, Bach to Beethoven, and on to the twentieth century of Einstein, Schoenberg, Stravinsky, Cage and Glass. A spellbinding examination of the interwoven fates of science and music throughout history.
https://abc7.com/weight-loss-drugs-ozempic-what-is-mounjaro-wegovy/13192740/
Obesity is a major and growing problem around the world, but especially in the U.S., where more than 40% of adults and about 20% of children now meet the criteria for what doctors say has become an intractable chronic disease.
Rates of the disease have soared in recent decades, spurred by the complex interaction of genes that make people more likely to store food as fat, a food system that provides easy and cheap access to processed treats explicitly designed to be overconsumed, and social settings that limit access to healthy options and exercise for many people.
Hepatic lipase is also closely related to obesity. In one test, an experiment was created by Cedó et al. where mouse cells were created to have a mutated HL protein that has lost its function. They found that a build-up of triglyceride levels led to nonalcoholic fatty liver disease.
Obesity is linked to scores of health problems that can lead to disability or even death, including high blood pressure, diabetes, heart disease, stroke, cancer and joint problems.
Researchers have long looked for medications that can help people lose weight, mostly with disappointing and, in some cases, dangerous results. In recent years, however, drugs designed to help people with type 2 diabetes control their blood sugar levels have had the added effect of paring pounds.
Ozempic, a Novo Nordisk drug approved to treat diabetes in 2017, Wegovy, a higher dose version of the same medication, called semaglutide, was approved for weight loss for adults in 2021 and for children aged 12 and older late last year.
Now, a new drug made by Eli Lilly and Co., called tirzepatide, is poised to become the most potent obesity drug on the market, promising users losses of more than 30 to 50 pounds over time. Already approved under the brand name Mounjaro to treat type 2 diabetes, tirzepatide is being considered for fast-track approval as a weight-loss drug based on the results of key trials, with the latest announced on Thursday.
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are hormones involved in blood sugar control.[7] After a person has eaten, these hormones are secreted by cells of the intestines and in turn cause the secretion of insulin. Tirzepatide is a GIP-analogue that activates both the GLP-1 and GIP receptors, leading to improved blood sugar control.[7]
It is produced and secreted by intestinal enteroendocrine L-cells and certain neurons within the nucleus of the solitary tract in the brainstem upon food consumption.
Semaglutide influences the Glucagon like peptide that belongs to a class of medications known as incretin mimetics. Wikipedia reports that GLP-1 stimulates gluconeogenesis, which is the process the body uses to make glucose from protein or fat. This process lowers blood sugar by stimulating glucose uptake into the cells and increasing how efficiently the body uses insulin. GLP-1 lowers hepatic (liver) glucose output, which helps lower blood sugar levels.
As gluconeogenesis increases, glucagon receptors are reduced in the liver, inhibiting glucose formation and stimulating glucose uptake by cells, thus lowering the amount of glucose in the blood.
A mathematical analysis of GlP 1 showed that the frequencies of GlP-1 medications correlate with the frequencies of hepatic lipase. This is associated with the idea that weight issues and insulin resistance are both related to the liver’s cholesterol functions.
The question that the Sound Health Institute will attempt to answer. Is the $2000 a month just an emulator of the frequencies of hepatic lipase and or does simply ingesting a form of hepatic lipase as a supplement have any bearing on stubborn weight loss issues and diabetes?