The mRNA in these vaccines codes for the spike protein normally synthesized by the SARS-CoV-2 virus. However, both the mRNA and the protein it produces have been changed from the original version in the virus with the intent to increase rate of production of the protein in an infected cell and the durability of both the mRNA and the spike protein it codes for. Additional ingredients like cationic lipids and polyethylene glycol are also toxic with unknown consequences. The vaccines were approved for emergency use based on grossly inadequate studies to evaluate safety and effectiveness.
Our paper showed that there are several mechanisms by which these vaccines could lead to severe disease, including autoimmune disease, neurodegenerative diseases, vascular disorders (hemorrhaging and blood clots), and possibly reproductive issues. There is also the risk that the vaccines will accelerate the emergence of new strains of the virus that are no longer sensitive to the antibodies produced by the vaccines. When people are immune compromised (e.g., taking chemotherapy for cancer), the antibodies they produce may not be able to keep the virus in check because the immune system is too impaired.
Just as in the case of antibiotic resistance, new strains evolve within an infected immune-compromised person’s body that produce a version of the spike protein that no longer binds with the acquired antibodies. These new strains quickly come to dominate over the original strain, especially when the general population is heavily vaccinated with a vaccine that is specific to the original strain. This problem is likely going to necessitate the repeated rollout of new versions of the vaccine at periodic intervals that people will have to receive to induce yet another round of antibody productio n in an endless game of cat and mouse.
Like the mRNA vaccines, the DNA vaccines are based on novel biotech gene editing techniques that are brand new, so they too are a massive experiment unleashed on a huge unsuspecting population, with unknown consequences. Both DNA vector vaccines have been associated with a very rare condition called thrombocytopenia, in which platelet counts drop precipitously, resulting in system-wide blood clots and a high risk of cerebral hemorrhaging [5]. This is likely due to an autoimmune reaction to the platelets, and it comes with a high risk of mortality. In the case of the AZ vaccine, this has caused over 20 European countries to temporarily pause their vaccination programs [6]. And the United States called a temporary halt on the J&J vaccine.
Even experts don’t really understand the mechanism as of now, although a fascinating theory to explain this depends on the fact that DNA vector vaccines require the DNA to be copied into RNA in the nucleus, and this presents the possibility of producing an incomplete copy, generated through “splice variants,” that is missing the code for attaching to the membrane [7]. These soluble partial sequences wander off to other parts of the body and bind to ACE2 receptors throughout the vasculature. Antibodies to these ACE2-bound partial spike fragments cause an acute inflammatory response that results in disseminated intravascular coagulation (DIC).
How an Adenovirus DNA Vector Vaccine is Made
The adenovirus vaccines are created through techniques that the average citizen can’t possibly fathom could even exist. For the AZ vaccine, the bulk of the DNA in the vaccine codes for the various proteins that are needed by a strain of adenovirus which mainly infects chimpanzees and causes cold-like symptoms [1]. However, it is not a “normal” version of this cold virus.
First of all, it has been stripped of certain genes that it needs in order to replicate, and for this reason it is referred to as an “adenovirus vector.” This defect, it is argued, keeps it from actually infecting the vaccinated patient.
Secondly, it is modified, through gene editing techniques, to create a recombinant version of the virus that contains the complete coding sequence for the SARS-CoV-2 spike protein, spliced into its DNA sequence – the same protein that the RNA vaccines code for. The recombinant DNA is a linear double-stranded DNA sequence where proteins from two different species are integrated through gene editing.