Masters of Health Magazine April 2025 | Page 51

Q: How does butyrate influence mood and neurotransmitter function?

  

A: Butyrate helps regulate key neurotransmitters, including GABA and dopamine. These neurotransmitters play critical roles in mood, anxiety, and reward responses. By supporting a healthy balance of these chemicals, butyrate contributes to better mental well-being and reduce symptoms of anxiety and depression.

Q: What role does butyrate play in preventing colon cancer?

 

 

A: Studies highlight that butyrate activates a receptor called GPR109a on colon cells (colonocytes) and certain immune cells. When switched on, this receptor triggers apoptosis (programmed cell death) in colon cancer cells, indicating that butyrate helps protect against colon cancer.

 

 

Q: How can I increase my butyrate levels for gut-brain benefits?

 

 

A: Consuming adequate dietary fiber (especially from starches, fruits, and vegetables) is key to boosting butyrate production. Fermented foods like homemade yogurt, kefir, and sauerkraut further enrich your gut microbiome, enhancing natural butyrate production. If you have severe gut issues, starting with easily digestible carbs (like dextrose water) and gradually increasing fiber intake is recommended to rebuild your gut health over time.

 

Sources and References

 

1 Nutrients. 2023 Oct 31;15(21):4631, Abstract

2 Cleveland Clinic, September 20, 2023, The Gut-Brain Connection

3, 4, 5, 6 Neuroscience Letters, Volume 625, June 20, 2016, Pages 56-63

7 Fermentation 2023, 9(3), 205

8 Molecular Brain, Volume 17, Article number: 4 (2024), Abstract

9 Antioxidants (Basel). 2022 Dec 20;12(1):4, Discussion

10 Brain Research, Volume 1806, May 1, 2023, 148286, Abstract

11 Front Neurosci. 2024 Feb 29;18:1304906, Discussion

12 Journal of Alzheimer’s Disease. 2020;74(1):91-99, Abstract

13 Front Immunol. 2022 Jun 24;13:937555

14 Vascular Pharmacology, Volume 115, April 2019, Pages 64-68

15 American Journal of Physiology. Endocrinology and Metabolism, Volume 319, Issue 6, December 2020, Pages E1019-E1030

16 Molecular and Cellular Endocrinology, Volume 418, Part 1, December 15, 2015, Pages 27-32

17 Nutrients. 2021 Jun 19;13(6):2099, Microbiota and Neurotransmitters

18 Cleveland Clinic, April 25, 2022, Gamma-Aminobutyric Acid (GABA)

19 Front. Microbiol, April 15, 2021, Sec. Microbial Physiology and Metabolism, Volume 12 - 2021, Introduction

20 Front. Microbiol, January 17, 2023, Sec. Microorganisms in Vertebrate Digestive Systems, Volume 14 - 2023, Impact of Neuroactive Compounds on the Gut

21 Biomedicines. 2022 Feb 13;10(2):436, Clostridium and Dopaminergic System

22 J Mol Neurosci. 2022 Feb;72(2):173-186

23 The University of Queensland, What Is Synaptic Plasticity?

24 Nutrients. 2024 Aug 29;16(17):2891, Intestinal Microbiota and BDNF

25 Front. Cell. Neurosci, April 15, 2020, Sec. Cellular Neurophysiology, Volume 14 - 2020, BDNF and Synaptic Plasticity

26 Molecular Brain, Volume 13, Article number: 43 (2020), Introduction

27 Translational Neurodegeneration, Volume 11, Article number: 4 (2022), Exogenous Administration of BDNF

28 Front. Cell. Neurosci, April 15, 2020, Sec. Cellular Neurophysiology, Volume 14 - 2020, Figure 2

29 Translational Neurodegeneration, Volume 11, Article number: 4 (2022), Clinical Investigations

30 Massachusetts General Hospital, October 16, 2024

31 Neurochemistry International, Volume 99, October 2016, Pages 110-132

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